About Us
Founded in 1944, the American Committee for the Weizmann Institute of Science develops philanthropic support for the Weizmann Institute in Israel, and advances its mission of science for the future of humanity.
https://www.weizmann-usa.org/news-media/in-the-news/the-coronavirus-unveiled/
Oct 09, 2020...
In February, as the new coronavirus swept across China and shut down entire cities, a scientist named Sai Li set out to paint its portrait.
At the time, the best pictures anyone had managed to take were low-resolution images, in which the virus looked like a barely discernible smudge.
Dr. Li, a structural biologist at Tsinghua University in Beijing, joined forces with virologists who were rearing the virus in a biosafety lab in the city of Hangzhou. Those researchers doused the viruses with chemicals to render them harmless and then sent them to Dr. Li.
Nov 05, 2020... REHOVOT, ISRAEL—November 5, 2020—Peculiar hybrid structures called retrons that are half RNA, half single-strand DNA are found in many species of bacteria. Since their discovery around 35 years ago, researchers have learned how to use retrons for producing single strands of DNA in the lab – yet despite extensive research into the matter, the retrons’ function in the bacteria was unknown. Now, in a paper published in Cell, Weizmann Institute of Science researchers report that the longstanding mystery has been solved: Retrons are immune system “guards” that ensure the survival of the bacterial colony when it is infected by viruses.
Nov 01, 2020... Seven years ago, an understanding of nature inspired a revolutionary new technology, when researchers turned a defense system used by bacteria to thwart viruses into the gene-editing tool now known as CRISPR. But for another emerging gene editor the understanding has lagged the applications. For several years, researchers have been adapting retrons—mysterious complexes of DNA, RNA, and protein found in some bacteria—into a potentially powerful way to alter genomes of single cell organisms. Now, biology is catching up, as two groups report evidence that, like CRISPR, retrons are part of the bacterial immune arsenal, protecting the microbes from viruses called phages.
Nov 24, 2020... Even before COVID-19, the lack of effective treatments for easily spread diseases was a serious concern for scientists and healthcare providers worldwide – particularly as one of humankind’s greatest achievements, antibiotics, are increasingly ineffective. This is because bacteria, like all life forms, are driven to reproduce and live. Able to evolve rapidly, they continually seek ways to survive our killer drugs … and they’re succeeding.
https://www.weizmann-usa.org/news-media/video-gallery/bacteria-in-tumors-improving-cancer-treatment/
Dec 17, 2020... This virtual conversation, hosted by the American Committee, features Weizmann’s Dr. Ravid Straussman, the NIH’s Dr. Daniel Douek (Chief of the Human Immunology Section of the Vaccine Research Center), and is moderated by Dr. Alan Leishner, former CEO of the American Association for the Advancement of Science, which publishes the prestigious journal Science.
Feb 01, 2021...
Many bacteria contain retrons, DNA sequences which code for enzymes that transcribe RNA into DNA and an unusual molecule made of both DNA and RNA. But microbiologists have puzzled over retrons’ function. “People suggested . . . this may be a selfish genetic element, [or] it may be involved in virulence,” says the Weizmann Institute of Science’s Rotem Sorek. “But nobody actually knew.”
See “Rotem Sorek Searches for Bacteria’s Defenses Against Viruses”
https://www.weizmann-usa.org/news-media/news-releases/bacteria-may-aid-anti-cancer-immune-response/
Mar 17, 2021... REHOVOT, ISRAEL—March 17, 2021—Cancer immunotherapy may get a boost from an unexpected direction: bacteria residing within tumor cells. In a new study published in Nature, researchers at the Weizmann Institute of Science and their collaborators have discovered that the immune system “sees” these bacteria and shown that they can be harnessed to provoke an immune reaction against the tumor. The study may also help clarify the connection between immunotherapy and the gut microbiome, explaining the findings of previous research showing that the microbiome affects the success of immunotherapy.
Mar 17, 2021...
Cancer cells present bacterial peptides on the outside of their walls, marking them as a foreign element to the body’s immune system, Weizmann Institute scientists report in a new article published in Nature.
This is crucial as while immunotherapy has been able to help melanoma cancer patients in roughly 40% of cases, the new findings could pave the road to more effective treatments and many lives saved in the future.
Apr 24, 2021... Exactly five years have passed since the moment the world of medicine most feared became reality. In the spring of 2016, in Pennsylvania, a 49-year-old woman suffering from an infection was attacked by a bacterium bearing the gene scientists had feared: MCR-1. It was the first time a bacterium with this gene had been discovered in a human being. The bad news: The bacterium was resistant to the strongest antibiotic that existed, colistin. The worse news was that it could easily transmit that resistance to other bacteria.
May 14, 2021... This summer, after more than a year of pandemic shutdowns, we are more excited than ever to get outside. But we can’t let down our guard when it comes to sun exposure, which is the primary cause of the most common cancer in the world: skin cancer. In fact, the Skin Cancer Foundation says that over 85% of melanomas are linked to UV radiation, and having more than five sunburns doubles your risk of developing this deadliest form of skin cancer.
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