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Showing results 21-31 of 81 for 'Genetics'

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    Gene Editing Takes on New Roles

    Two new and powerful research methods – CRISPR gene editing and single-cell genomic profiling – have now been combined to produce a tool fine enough to enable scientists to observe life's most nuanced processes. Prof. Ido Amit and his lab have so refined CRISPR that scientists can understand biological processes in shades of grey – not just black and white.

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    Natural Metabolite Might Reset Aging Biological Clocks

    As we age, our biological clocks wind down – but why? Dr. Gad Asher, who studies circadian clocks – genetic mechanisms that keep us in tune with cycles of day and night – has identified a link between the clocks and a group of metabolites called polyamines. Found in many foods, polyamines could fight aging – as they did in Dr. Asher's mice.

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    One Patent, Three Drugs

    Many years ago, Prof. Michael Sela and colleagues found that antibodies inhibiting EGFR, a receptor that plays a role in cancer, have a synergistic anti-cancer effect when used with chemotherapy. That discovery has now led to three cancer-treating drugs: Erbitux<sup>®</sup>, Vectibix<sup>®</sup>, and, most recently, Portrazza<sup>™</sup>, just FDA approved for a form of lung cancer.

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    Human Primordial Cells Created in the Lab

    Weizmann's Dr. Jacob Hanna and Cambridge University scientists have made a first-in-the-world breakthrough: creating human primordial cells. The group has turned back the clock on human cells to create primordial germ cells: the embryonic cells that give rise to sperm and ova. Scientists worldwide have been pursuing this goal for several years.

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    Why do Female Mice Attack Others' Pups? Blame it on Pheromones

    Lab mice lose many of their natural traits; e.g., lab females will care for others' pups, unlike their wild cousins. Dr. Tali Kimchi has developed a model that lets her explore, for the first time, the biological roots of aggressiveness in females, particularly toward pups, and found that pheromones are the key. Her work could aid gender-specific drug development.

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    Science Tips, July 2014

    Three updates from the labs of the Weizmann Institute: with interferons, even the negative may be necessary when it comes to HIV; mutations harmful to fertility are different in men and women; tiny magnets point to a fundamental principle of particle physics.

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    Rare Disorder Found to Have a Common Form

    An autoimmune disease, thought to be very rare, may have a less severe form that affects at least one in 1,000 people. The research, by Weizmann and Norway's University of Bergen, suggests that other autoimmune conditions may be tied to mutations in a single gene, and could lead to new diagnostic and treatment methods for autoimmune disorders.