To the list of reasons that chemotherapy sometimes does not work, we can now add one more: bacteria. In a study just published in Science, researchers describe their findings showing that certain bacteria can be found inside human pancreatic tumors. The findings further revealed that some of these bacteria contain an enzyme that inactivates a common drug used to treat various cancers, including pancreatic cancer. Working with mouse models of cancer, the scientists demonstrated how treatment with antibiotics on top of chemotherapy may be significantly superior to treatment with chemotherapy alone.
September 14, 2017
Ever wanted to know how to fix a broken heart? What a scratch, pneumonia, and soil pollution have in common? Why insects could be the food of the future? Researchers’ Night at the Weizmann Institute of Science is an evening dedicated to science for everyone – to answering any and all questions about science. Researchers’ Night has been taking place annually at the Weizmann Institute of Science since 2006, as part of the European Union Researchers’ Night event that takes place in hundreds of sites all over Europe. In Israel, it occurs within a nationwide framework of activities at academic research institutes and science museums and is supported by the Israeli Ministry of Science, Technology and Space. Researchers’ Night at the Weizmann Institute is organized by the Davidson Institute of Science Education, the Weizmann Institute’s educational arm.
August 2017
It is said that a weak link determines the strength of the entire chain. Likewise, defects or small cracks in a solid material may ultimately determine the strength of that material – how well it will withstand various forces. For example, if force is exerted on a material containing a crack, large internal stresses will concentrate on a small region near the crack’s edge. When this happens, a failure process is initiated, and the material might begin to fail around the edge of the crack, which could then propagate, leading to the ultimate failure of the material.
August 24, 2017
The proteins in our bodies are social molecules. But now and again, new ties between proteins can get you into trouble. For example, when hemoglobin – the protein complex that carries oxygen in our blood – undergoes just one mutation, the complexes stick to one another, stacking like Lego blocks to form long, stiff filaments. These filaments, in turn, elongate the red blood cells found in sickle-cell disease. For over 50 years, this has been the only known textbook example in which a mutation causes these filaments to form. According to Dr. Emmanuel Levy and his group in the Weizmann Institute of Science’s Structural Biology Department, Lego-like assemblies should have formed relatively frequently during evolution, and so they asked: How easy is it to get proteins to stack into filaments? Their answer, which was recently published in Nature, may have implications for both biological research and nanoscience.
August 2017
Color in the plant kingdom is not merely a joy to the eye. Colored pigments attract pollinating insects, they protect plants against disease, they confer health benefits, and are used in the food and drug industries. A new study conducted at the Weizmann Institute of Science, published in the Proceedings of the National Academy of Sciences, USA, has now opened the way to numerous potential uses of betalains, the highly nutritious red-violet and yellow pigments known for their antioxidant properties and commonly used as food dyes.
August 2017
One of the first organ systems to form and function in the embryo is the cardiovascular system: in fact, this developmental process starts so early that scientists still have many unresolved questions on the origin of the primitive heart and blood vessels. How do the first cells – the progenitors – that are destined to become part of this system participate in shaping the developed cardiovascular system? Dr. Lyad Zamir, a former PhD student in the lab of Prof. Eldad Tzahor in the Weizmann Institute of Science’s Department of Molecular Cell Biology, developed a method to image the earliest cardiovascular progenitors and track them and their descendants through the developing embryo in real time. His movies took place in fertilized chicken eggs, in which a complex network of blood vessels forms within the yolk sac to nourish the embryo. The findings of this research were recently published in eLife.
August 2017
Every time we swallow food, cells that line the intestines must step up their activity in a sudden and dramatic manner. According to a new study by Weizmann Institute of Science researchers, reported in Science, they rise to the challenge in the most economic fashion. In business or engineering, when one has to get production underway quickly, instant decisions are made. These might involve instantly throwing all one’s resources into boosting production with existing equipment, or else first spending all those resources to equip the plant with proper machinery. The latter might seem to be a less efficient production method but it can actually, in some cases, speed things up considerably. Dr. Shalev Itzkovitz and his team in the Department of Molecular Cell Biology discovered that this is just the method adopted in the lining of the intestinal wall.
August 2017
The Nature Index of Innovation, published August 9, 2017, places the Weizmann Institute of Science in sixth place in an international ranking of the world’s top 200 research institutions. To determine placements, the Nature Index – affiliated with renowned scientific journal Nature – examined how research articles are cited in third-party patents, then ranked the institutions according to the impact produced by their academic research.The rationale for this process is that by looking at patents owned by third parties – informed by and citing academic work – rather than those held by institutions themselves, the influence of research on the development of products and services is exposed. According to Nature, the academic players featured in the index are those “whose ideas may shape tomorrow’s inventions. The top of these tables are occupied by both institutions with global reputations for high-quality research and others whose published work is having a disproportionately high impact relative to their size.”
August 09, 2017
Scientists have managed to design microscopic silk capsules that mimic, on a very small scale, the structure of silkworm cocoons. The capsules can serve as a protective environment for the transport of sensitive “cargo” such as natural silk proteins, antibodies, or other delicate molecules. The collaborative research – which was performed by an international team of academics from the Weizmann Institute of Science in Israel; the Universities of Cambridge, Oxford, and Sheffield in the UK; and the ETH in Switzerland – may lead to a host of applications in the cosmetics, food, and pharmaceutical industries, particularly in the delivery of drugs within the body. The findings were reported in Nature Communications.
July 20, 2017
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