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Showing results 81-91 of 92 for 'Cancer treatment'

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    Coaxing the Immune System to Fight Cancer

    Immuno therapy was once the black sheep of cancer research. Originally conceived over a century ago, it aims to stimulate a patient’s own immune system to fight cancer. That’s a very different approach than chemotherapy, which essentially poisons tumors.

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    Working Toward Personalized Cancer Treatment

    “We don’t just want to find the genes involved in cancer,” says Prof. Yardena Samuels, of the Weizmann Institute of Science’s Department of Molecular Cell Biology, “we want to understand what those genes do. We want to reveal the complete picture of a cancer genome.” That is something of a tall order, considering that cells from melanoma, the cancer Prof. Samuels is researching, can contain anywhere from tens to thousands of mutations. On average, melanoma – the deadliest form of skin cancer – has more mutations in the DNA of its cells than any other solid tumor. Among other things, this range of mutations explains why a recent treatment designed to target melanoma will only help around 50% of those with the disease, despite representing a large step forward.

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    Combined Approach Offers Hope to Lung Cancer Patients Who Become Resistant to Drugs

    New-generation lung cancer drugs have been effective in a large number of patients, but within about a year, most tend to develop resistance to the therapy. Researchers at the Weizmann Institute of Science, in collaboration with physicians, have conducted a study in mice in which they used existing drugs in a new combination to help crush potential treatment resistance. Their findings were published recently in the journal Clinical Cancer Research.

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    Disrupted Nitrogen Metabolism Might Spell Cancer

    When the body makes use of nitrogen, it generates from the leftovers a nitrogenous waste substance called urea in a chain of biochemical reactions that take place in the liver, which are known as the urea cycle. As a result of this cycle, urea is expelled into the bloodstream, and is later excreted from the body in the urine. In previous research, Dr. Ayelet Erez of Weizmann’s Department of Biological Regulation showed that one of the enzymes in the urea cycle has been inactivated within many cancerous tumors, thus increasing the availability of nitrogen for the synthesis of an organic substance called pyrimidine which, in turn, supports RNA and DNA synthesis and cancerous growth.

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    Toward an “Ultra-Personalized” Therapy for Melanoma

    With new immunotherapy treatments for melanoma, recovery rates have risen dramatically – in some cases to around 50%. But they could be much higher. A new study led by researchers at the Weizmann Institute of Science showed, in lab dishes and animal studies, that a highly personalized approach could help the immune cells improve their ability to recognize the cancer and kill it. The results of this study were published in Cancer Discovery.

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    Repairing DNA, Fighting Cancer

    Our genetic material – DNA – is under constant assault. It is damaged every day by external forces like sunlight, radiation, tobacco smoke, air pollution, and food additives, and internal ones like waste products left over from the body’s metabolic processes.